I wasn't too crazy about the first Jodi Picoult book I read, The Pact; it was hard to put down but very dark. My Sister's Keeper, however, was even harder to put down and without the despair. The subject matter seems despairing enough: one sister, conceived specifically as a perfect genetic match for her leukemia-ridden sister, fights to be medically emancipated. Several other stories are woven in with this one, and all the side stories were compelling, as well. I wasn't sure I wanted to read another Picoult book after The Pact, but I'm glad I did.